STITCH: Chemical-Protein Interactions

STITCH is a resource to explore known and predicted interactions of chemicals and proteins. Chemicals are linked to other chemicals and proteins by evidence derived from experiments, databases and the literature.
  
STITCH contains interactions for over 68,000 chemicals and over 1.5 million proteins in 373 species.

To explore the interactions of the beta blocker propanolol, enter its name or an identifer like the ATC Code C07AA05 in the search box to the left. Select 'Homo Sapiens' as organism. When you click GO!, you will be taken to a table with various functionally related proteins: adrenergic receptors (the primary targets), serotonin receptors (which are also targeted) and the metabolizing Cytochrome P450 enzymes. Click on "Summary Network" to view a graphical representation. When you click on one of the adrenergic receptors, you can add it to the set of input nodes. This will result in a network containing both proteins and related chemicals.

STITCH (Search Tool for Interactions of Chemicals) is a sister project of the protein-protein interactions server STRING. The database of chemicals is based on PubChem. Up-to-date genomes and proteomes are maintained at UniProtKB/Swiss-Prot and Ensembl. To be informed about the latest developments, please subscribe to the STRING/STITCH blog.
STITCH references: Kuhn et al. 2008 Miscellaneous: Access Statistics, Robot Access Guide, Medusa Network Viewer, Supported Browsers.
Warning: This is an archived version of STITCH. Please visit the current version.